A state official said a monkey pox case was reported in Mexicali.
Another case was reported in Tijuana and a third one in Ensenada.
Previously, the Department of Public Health dismissed a case recorded in Ensenada.
State Secretary of Public Health Adrián Medina said the patients are all male of 30, 54 and 49 years of age.
In all cases, patients previously traveled to the US or other parts of Mexico.
In the local case, Sec. Medina said the 54-year-old visited San Diego. Other four cases have been recorded in Baja California, the state official said.